I just listened to the first six minutes and 20 seconds of Wil Wheaton's Keynote Address at PAX '07. It is awesome. It is rated R, certainly, but before anything else, Wil fully qualifies himself as a huge geek. And just to let you know, I got every one of his gaming references except "Beware, I Live".
It is quite an excellent and well-delivered speech, and yes he does drop references to his roles in Stand By Me and Star Trek, The Next Generation. I've put the whole thing on my mp3 player, and plan to listen to it tomorrow morning. I highly recommend it.